Mlodzik Lab - Publications


Selected Publications (in reverse chronological order since 1994), out of total of >150


Carvajal-Gonzalez, J.M., Roman, A-C., and Mlodzik, M. (2016). Positioning of centrioles is a conserved read-out of Frizzled planar cell polarity signaling. Nature Communications, 7, 11135. doi: 10.1038/ncomms11135. PMCID: PMC4820615

Mlodzik, M. (2016). The Dishevelled Protein Family: Still rather a mystery after over 20 Years of molecular studies. Curr Top Dev Biol. (P. Wassarman editor; Elsevier), 117, 75-91. PMCID: PMC4939608

Kelly, L.K., Wu, J., Yanfeng, W.A., and Mlodzik, M. (2016). Frizzled induced Van Gogh phosphorylation by CK1ε promotes asymmetric localization of core PCP factors in Drosophila. Cell Reports, 12, 344-356. PMCID: PMC4945453

Vega-Macaya F, Manieu C, Valdivia M, Mlodzik M, and Olguín P. (2016). Establishment of the Muscle-Tendon Junction During Thorax Morphogenesis in Drosophila Requires the Rho-Kinase. Genetics 204, 1139-1149. PMCID: PMC5105847

Carvajal-Gonzalez J.M., Mulero-Navarro S, Smith, M., and Mlodzik, M. (2016). A Novel Frizzled-Based Screening Tool Identifies Genetic Modifiers of Planar Cell Polarity in Drosophila wings. G3, 6, 3963-3973. PMCID: PMC5144966

Carvajal-Gonzalez, J.M., Mulero-Navarro, S., and Mlodzik, M. (2016). Centriole Positioning in epithelial cells and its intimate relationship with Planar Cell Polarity. BioEssays, 38, 1234-1245. PMCID: PMC5206807


Carvajal-Gonzalez, J.M., Balmer, S., Mendoza, M., Dussert, A., Collu, G., Weber, U., Ciruna, B. and Mlodzik, M. (2015). The Clathrin Adapter AP-1 complex and Arf1 regulate Planar Cell Polarity in vivo. Nature Communications 6, 6751.doi: 10.1038/ncomms7751. PMCID: PMC4515971

Collu G.M. and Mlodzik, M. (2015). Planar Polarity: Converting a Morphogen Gradient into Cellular Polarity. Current Biology 25, 372-374. PMCID: PMC4526819

Balmer, S., Dussert, A., G. Collu, Benitez, E., Iomini, C., and Mlodzik, M. (2015). Components of Intraflagellar transport complex A (IFT-A) function independently of the cilium to regulate canonical Wnt signaling in Drosophila. Developmental Cell, 34, 705-718. PMCID: PMC4610147.

Yang, Y., and Mlodzik M. (2015). Wnt/Frizzled Planar Cell Polarity (PCP) signaling: Cellular Orientation by facing the wind  (Wnt). Ann. Reviews in Cell and Dev. Biology, 31, 623-646. PMCID: in process.


Carvajal-Gonzalez, J.M. and Mlodzik, M. (2014). Mechanisms of Planar cell polarity establishment in Drosophila. F1000 Prime Reports, 6:98 (doi:10.12703/P6-98). PMCID: PMC422972

Weber, U., Rodriguez, E., Martignetti, J. and Mlodzik, M. (2013). Luna, a Drosophila KLF6/KLF7, is maternally required for synchronized nuclear and centrosome cycles in the preblastoderm embryo.  PLoS One, 9, e96933. PMCID: PMC4051582

Serysheva, E., Mlodzik, M.* and Jenny, A.* (2013).  Wnks in Wnt/beta-catenin signaling. Cell Cycle, 13, 173-174. *co-senior and corresponding authors  PMCID: PMC3906229


Chin, M.L. and Mlodzik, M. (2013). Drosophila Furrowed/Selectin is a homophilic cell adhesion molecule stabilizing Frizzled and mediating its intercellular interactions during PCP establishment. Developmental Cell, 26, 455-468. PMCID: PMC4084690.

Wu, J., Roman, A., Carvajal-Gonzalez, J.M., and Mlodzik, M. (2013). Wg and Wnt4 provide long-range directional input to planar cell polarity orientation in Drosophila. Nature Cell Biology, 15, 1045-1055. PMCID: PMC3762953. [with Cover]

Grumolato L., Liu G., Haremaki T., Mungamuri S.K., Mong P., Akiri G., Lopez-Bergami P., Arita A., Anouar Y., Mlodzik M., Ronai Z.A., Brody J., Weinstein D.C., and Aaronson S.A. (2013). β-Catenin-Independent Activation of TCF1/LEF1 in Human Hematopoietic Tumor Cells through Interaction with ATF2 Transcription Factors. PLoS Genetics 9, e1003603. doi:10.1371/journal.pgen.1003603 PMCID: PMC3744423

Muñoz-Soriano, V., Ruíz, C., Pérez-Alonso, M., Mlodzik, M. and Paricio, N. (2013). Nemo regulates cell dynamics and represses the expression of miple, the Drosophila midkine/pleiotrophin homolog, during ommatidial rotation. Developmental Biology 377, 113-125.  PMCID: PMC3839108

Serysheva, E., Berhane, H., Grumolato, L., Demir, K., Balmer S, Bodak M., Boutros, M., Aaronson, S.A., Mlodzik, M.*  and Jenny, A.* (2013). Wnk kinases are positive regulators of Wnt/b-catenin signaling. EMBO R. 14, 718-25. *co-senior and corresponding authors. PMCID: PMC3736136


Singh, J. and Mlodzik, M. (2012). Planar cell polarity signaling: coordination of cellular orientation across tissues. WIREs Dev. Biology doi: 10.1002/wdev.32 PMCID: PMC3467146

Singh, J., and Mlodzik, M. (2012). Hibris, a Drosophila Nephrin homologue, is required for Presenilin mediated Notch and APP-like cleavages. Developmental Cell 23, 82-96. PMCID: PMC3475182 

Gault, W.J., Olguin, P., Weber, U., and Mlodzik, M. (2012). Drosophila CK1γ, gilgamesh, Controls PCP-mediated Morphogenesis Through Regulation of Vesicle Trafficking. J. Cell Biology, 196, 605-621. PMCID: PMC3307696

Weber, U., Gault., W.J., Olguin, P., Serysheva, E, and Mlodzik, M. (2012). Novel Regulators of Planar Cell Polarity: A Genetic Analysis in Drosophila. Genetics 191, 145-162. PMCID: PMC3338256


Olguin, P., Glavic, A., and Mlodzik, M. (2011). Inter-tissue mechanical stress affects Frizzled-mediated planar cell polarity in the Drosophila notum epidermis. Current Biology, 21, 236-242. PMCID: PMC3057393

Blitzer, A.L., Panagis, L., Gusella, G.L., Danias, J., *Mlodzik, M., and *Iomini, C. (2011). Primary cilia dynamics instruct tissue patterning and repair of corneal endothelium. Proc/ Natl. Acad. Sci (USA) 108, 2819-2824. *co-corresponding authors. PMCID: PMC3041123

Grumolato, L., Weber, U., and Mlodzik, M. (2011) Another piece to the unsolved Planar Cell Polarity puzzle. Dev. Cell 20, 146-147.

Mirkovic, I., Gault, W.J., Rahnama, M., Jenny, A., Gaengel, K., Bessette, D, Gottardi, C.J., Verheyen, E.M., and Mlodzik, M. (2011). The Nemo kinase connects core PCP factors to E-cadherin/b-catenin during ommatidial rotation in the Drosophila eye. Nature Struct. Mol. Biol., 18, 665–672. PMCID: PMC3109122

Yanfeng, W. A., Berhane, H., Mola, M., Singh, J., Jenny, A., and Mlodzik, M. (2011) Functional dissection of phosphorylation of Dishevelled in Drosophila. Developmental Biology 360, 132-142. PMCID: PMC3221411

Wong, J.S., Iorns, E., Rheault, M.N., Ward, T.M., Rashmi, P., Weber, U., Lippman, M.E., Faul, C., Mlodzik, M. and Mundel, P. (2011). Rescue of tropomyosin deficiency in Drosophila and human cancer cells by synaptopodin reveals a role of tropomyosin a in RhoA stabilization. EMBO J., 31, 1028-1040. PMCID: PMC3280558


Singh, J., Aaronson, S.A., and Mlodzik, M. (2010). Drosophila Abelson kinase mediates cell invasion and proliferation via two distinct MAPK pathways. Oncogene, 29, 4033-4045. PMCID: PMC2919309

Djiane, A., and Mlodzik M. (2010). The Drosophila GIPC homologue can modulate myosin based processes and planar cell polarity but is not essential for development. PLoS One, e11228. PMCID: PMC2888583

Olguin, P., and Mlodzik, M. (2010), A new spin on planar cell polarity. Cell 142, 674-676. PMCID: PMC2944088

Singh, J., Grumolato, L., Aaronson, S.A., and Mlodzik, M. (2010). Abelson family kinases regulate Frizzled planar cell polarity signaling via Dsh phosphorylation. Genes & Development 24, 2157-2168. PMCID: PMC2947768

Song, J.K., Kannan, R., Merdes, G., Singh J., Mlodzik M., and Giniger R. (2010). Disabled is a bona-fide component of the Abl signaling network. Development, 137, 3719-3727. PMCID: PMC2964101


Simons, M., Gault, W.J., Gotthardt, D., Rohatgi, R, Klein, T.J., Shao, Y., Lee, H.-J., Wu, A.-L., Fang, Y., Satlin, L.M., Dow, J.T., Chen, J., Zheng, J., Boutros, M., and Mlodzik, M. (2009). Electrochemical cues regulate the assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization. Nature Cell Biology, 11, 286-294. PMCID: PMC2803043

Mlodzik, M. (2009). Ubiquitin connects with planar cell polarity. Cell, 137, 209-211.

Skouloudaki, K., Puetz, M., Simons, M., Courbard. J.R., Boehlke, C., Hartleben, B., Engel, C., Moeller, M.J., Englert, C., Bollig, F., Schäfer, T., Ramachandran, H., Mlodzik, M., Huber, T.B., Kuehn, E.W., Kim, E., Kramer-Zucker, A., and Walz, G. (2009). Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development. Proc. Natl. Acad. Sci. (USA), 106, 8579-8584. PMCID: PMC2688978

Wu, J. and Mlodzik, M. (2009). A quest for the mechanism regulating global planar cell polarity of tissues. Trends in Cell Biology, 19, 295-305.

Courbard, J.R., Djiane, A., Wu, J., and Mlodzik, M. (2009). The apical/basal-polarity determinant Scribble cooperates with the PCP core factor Stbm/Vang and functions as one of its effectors. Developmental Biology, 333, 67-77. PMCID: PMC3011816


Del Alamo, D. and Mlodzik, M. (2008). Self-modulation of Notch signaling during ommatidial development via the roughened eye transcriptional repressor. Development, 135, 2895-2904.

Wu, J., and Mlodzik, M. (2008). The Frizzled extracellular domain is a ligand for Van Gogh/Strabismus during non-autonomous planar cell polarity signaling. Developmental Cell, 15, 462-469. PMCID: PMC2814157

Simons, M., and Mlodzik, M. (2008). Planar Cell Polarity: from Fly Development to Human Disease.  Annual Reviews in Genetics, 42, 517-40. PMCID: PMC2814158


Seifert, J.R.K., and Mlodzik, M (2007) Frizzled/PCP signaling: a conserved mechanism regulating cell polarity and directed motility. Nature Reviews Genetics, 8, 126-138.

Curtiss, J., Burnett, M. and Mlodzik, M. (2007). Distal antenna and distal antenna related function in the retinal determination network during eye development in Drosophila. Developmental Biology, 306, 685-702. PMCID: PMC1986786


Ciruna, B., Jenny, A., Lee, D., Mlodzik, M. and Schier A.F. (2006). Planar cell polarity signalling couples cell division and morphogenesis during neurulation. Nature, 439, 220-224.

Klein, T.J., Jenny, A., Djiane, A. and Mlodzik, M. (2006). CKIe/discs overgrown promotes both Wnt-Fz/b-Catenin and Fz/PCP signaling in Drosophila. Current Biology, 11, 1337-1343.

Mlodzik, M. (2006). A GAP in convergent extension scores a PAR. Developmental Cell, 11, 2-4.

Delaney, J.R., Stöven, S., Uvell, H., Anderson, K.V., Engström, Y. and Mlodzik, M. (2006). Cooperative control of Drosophila immune responses by the JNK and NF-kB signaling pathways. EMBO J., 25, 3068-3077.

Mirkovic, I. and Mlodzik M. (2006). Cooperative activities of Drosophila DE-Cadherin and DN-Cadherin regulate the cell motility process of ommatidial rotation.   Development, 133, 3283-3293.

Del Alamo, D. and Mlodzik, M. (2006). Frizzled/PCP signaling mediated asymmetric Neuralized expression determines planar cell polarity and R3/R4 fates in the Drosophila eye. Developmental Cell, 11, 887-894.


Djiane,  A., Yogev,  S., and Mlodzik, M. (2005). The apical determinants aPKC and dPatj regulate Frizzled-dependent planar cell polarity in the Drosophila eye.  Cell 121, 621-631.

Jenny, A., Reynolds-Kenneally, J., Das, G., Burnett, M. and Mlodzik, M. (2005). Dishevelled is protected by Diego from the antagonistic effect of the Stbm/Prickle complex during Fizzled-PCP signaling.  Nature Cell Biology 7, 691-697.

Dollar, G., Weber, U., Mlodzik, M. and Sokol, S., (2005). Regulation  of Lethal Giant Larvae by Dishevelled. Nature 437, 1376-1380.

Klein, T.J., and Mlodzik, M. (2005). Planar cell polarization: An emerging model points in the right direction. Ann. Reviews in Cell and Dev. Biology21,  155-176.


Klein, T.J., and Mlodzik M. (2004). Flies like us: A conserved signaling cassette regulates hair patterning from Drosophila to man. Proc. Natl. Acad. Sci. (USA), 101, 9173-0174.

Wu, J., Klein, T..J. and Mlodzik,  M. (2004). Subcellular localization of Frizzled receptors, mediated by their cytoplasmic tails, regulates signaling specificity and read-out. PLoS Biology, 2, 1004-1014.

Das, G., Jenny, A., Klein, T.J., Eaton, S., and Mlodzik, M (2004). Diego interacts with Prickle and Strabismus/Van Gogh to localize planar cell polarity complexes.  Development, 131, 4467-4476.


Jenny, A., Darken, R. Wilson, P.A. and Mlodzik, M. (2003). Prickle and Strabismus form a functional complex to generate a correct axis during planar cell polarity signaling.   EMBO J., 22, 4409-4420. 

Weber, U., Eroglu, C. and Mlodzik, M. (2003). Phospholipid membrane composition affects EGF-Receptor and Notch signaling through effects on membrane traffic during Drosophila development.  Developmental Cell, 5, 559-570.


Curtiss, J., Halder, G. and Mlodzik, M. (2002). Selector and signaling molecules cooperate in organ patterning. Nature Cell Biology 4, 48-51.

Das, G., Reynolds-Kenneally, J.  and Mlodzik, M. (2002). The atypical  Cadherin Flamingo  links Frizzled and Notch signaling in planar polarity establishment in the Drosophila eye. Developmental Cell 2, 655-666.


Feiguin, F., Hannus, M., Mlodzik, M. and Eaton, S. (2001). The Ankyrin repeat protein Diego mediates Frizzled-dependent planar polarization and formation of proximal-distal cortical domains. Develelopmental Cell 1, 93-101.


Boutros, M., Mihaly, J., Bouwmeester, T. and Mlodzik, M. (2000). Signaling specificity by Frizzled receptors in Drosophila. Science 288, 1825-1828.

Weber U, Paricio N, Mlodzik M. (2000). Jun mediates Frizzled-induced R3/R4 cell fate distinction and planar polarity determination in the Drosophila eye. Development 127, 3619-3629.

Fanto, M., Weber, U. Strutt, D.I. and Mlodzik, M. (2000). Nuclear signaling by Rac and Rho GTPases is required in the establishment of epithelial planar polarity in the Drosophila eye. Current Biology 10, 979-988.


Fanto, M. and Mlodzik, M. (1999). Asymmetric Notch activation downstream of Frizzled signaling specifies photoreceptors R3 and R4 and generates planar polarity in the Drosophila eye. Nature 397, 523-526.

Paricio, N., Feguin, F., Boutros, M., Eaton, S. and Mlodzik, M. (1999). The Drosophila STE20-like kinase Misshapen is required downstream of the Frizzled receptor in planar polarity signaling. EMBO J. 18, 4669-4687.

Goberdhan, D.C.I., Paricio, N., Goodman E., Mlodzik M. and Wilson C. (1999). Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3 kinase signaling pathway. Genes & Dev. 13, 3244-3258.

Mlodzik, M. (1999). Planar polarity in the Drosophila eye: a multifacetted view of signaling specificity and crosstalk. EMBO J. 18,  6873-6879


Boutros, M., Paricio, N., Strutt, D.I. and Mlodzik, M. (1998). Dishevelled activates JNK and discriminates between JNK pathways in planar polarity and wingless signaling.  Cell 94, 109-118.


Yuan, Y.P., Schultz, J., Mlodzik, M. and Bork, P. (1997). Secreted Fringe-like glycosyltransferases as signaling molecules in pattern formation? Cell 87, 9-11.

Strutt, D.I., Weber, U. and Mlodzik, M. (1997). The role of RhoA in tissue polarity and Frizzled signalling. Nature 387, 292-296.

Kockel, L., Zeitlinger, J., Staszewski, L.M., *Bohmann, D.and *Mlodzik, M (1997). Jun in Drosophila development: Redundant and non-redundant functions, and regulation by two MAPK signal transduction pathways. Genes & Dev. 11, 1748-1758.  *co-senior and corresponding authors

Zeitlinger, J., Kockel, L., Peverali, F.A., Jackson, D.B., *Bohmann, D. and *Mlodzik, M. (1997). Defective dorsal closure and loss of decapentaplegic  expression in Drosophila fos mutants. EMBO J. 16, 7393-7401. *co-senior and corresponding authors


Zeidler, M., Yokomori, K., Tjian, R. and Mlodzik, M. (1996). Drosophila  TFIIA-S is up-regulated and required during Ras mediated photoreceptor determination. Genes & Dev. 10, 50-59.

Wiersdorff, V., Lecuit, T., Cohen, S.M. and Mlodzik, M. (1996). Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye. Development 122, 2153-2162.


Strutt, D.I., Wiersdorff, V. and Mlodzik, M. (1995). Regulation of furrow progression in the Drosophila eye by cAMP-dependent protein kinase A. Nature 373, 705-709.

Treier, M., Bohmann, D. and Mlodzik, M. (1995). Jun cooperates with the ETS-domain protein Pointed to induce photoreceptor R7 fate in the Drosophila eye. Cell 83, 753-760.


Bohmann, D., Ellis, M.C., Staszewski, L.M. and Mlodzik, M. (1994). Drosophila Jun mediates Ras-dependent photoreceptor determination. Cell 78, 973-986.