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http://icahn.mssm.edu/departments-and-institutes/developmental-and-regenerative-biology
 

Ghaffari Lab - Publications

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Publications since:


2015


Rimmelé P*., Liang R*., Bigarella C*., Zhang A., Sadek H. and S. Ghaffari. Mitochondrial metabolism in hematopoietic stem cells requires functional FOXO3.EMBO Reports 2015 Sep;16(9):1164-76.


Liang R*., Camprecios G*., Kou Y., McGrath K., Nowak R., Catherman S., Bigarella C.L., Rimmelé P., Zhang X., Gnanapragasam MN, Bieker J.J., Papatsenko D., Ma’yan A., Bresnick E., Fowler V., Palis J., and S. Ghaffari

A Systems Approach Identifies Essential FOXO3 Functions at Key Steps of Terminal Erythropoiesis. PLoS Genetics 2015, Oct 9; 11 (10): e1005526


Price G.J., Idoyaga J., Salmon H., Hogstad B., Bigarella C.L., Ghaffari S., Leboeuf M. and M. MeradCDKN1A regulates Langerhans cell survival and promotes Treg cell generation upon exposure to ionizing irradiation., Nature Immunology, 2015; 16(10):1060-8.


2014


Rimmelé P., C. Bigarella, Izac B., R., Dieguez-Gonzalez, M. Donovan, C. Brugnara, D. Sinclair and S. Ghaffari. Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells. Stem Cell Reports, 3 (1): 44-59, 2014


S. Ghaffari. PIAS adds methyl-bias to HSC-differentiation. Have You Seen EMBOJ 2014  1;33 (2):93-5.


Rimmelé P., Lofek S., S. Ghaffari. Resveratrol increases the bone marrow hematopoietic stem and progenitor cell capacity. American Journal of Hematology, 2014; 89(12):E235-8.


Bigarella, C*., Liang R.* and S. Ghaffari. Stem cells and the impact of ROS signaling Development 2014; 141(22):4206-18.


Zhang, X., Camprecios G., Yalcin S., Mungamuri, SH., Barminko, J., Rimmele P., Liang R., Baron M., Brugnara C., Papatsenko D., Rivella S., and S. Ghaffari. FOXO3-mTOR metabolic cooperation in the regulation of erythroid cell maturation and homeostasis. American Journal of Hematology. 20 (12):1902-16, 2014.


McIver, S.C., Kang, Y.A., DeVilbiss A.W., O’Driscoll C.A., Ouellette J.N., Pope N.J., Camprecios G., Chang C-J, Yang D., Bouhassira E.E., Ghaffari S., Bresnick E.H. The exosome complex establishes a barricade to erythroid maturation. Blood, 2014-04-571083.


Liang R. and S. Ghaffari. Stem cells, redox signaling, and stem cell aging. Anti-oxidant & Redox Signaling, 2014, Epub ahead of print, 20 (12): 1902-1916, 2014.


S. Santos Franco, L. De Falco, S. Ghaffari, C. Brugnara, D.A. Sinclair, L. De Franceschi. Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice. Hematologica, 2014, 99(2):267-75.



2011-2013


P. Ramos, C. Casu, S. Gardenghi, L. Breda, B. Crielaard, E. Guy, M.F. Marongiu, R. Gupta, R. L. Levine, O. Abdel-Wahab, B.L. Ebert, N. Van Rooijen, S. Ghaffari, R.W. Grady, P.J. Giardina and S. Rivella. Macrophages support pathological erythropoiesis in polycythemia vera and -thalassemia. Nature Medicine 2013 Apr;19(4):437-45.


Zhang X., Yalcin S., Lee D.F., Lee S-M, Yeh T.Y.J., Jie S., Kennedy M., Sellers R., Landthaler, M., Tuschl T, Chi N.W., Lemischka I., Keller G. and S. Ghaffari. FoxO1 is an essential regulator of human ES cell pluripotency. Nature Cell Biology 13 (9): 1092 – 99, 2011, Jul 31 (highlighted in Cell Stem Cell: 9 (3), p181, 2011).


Zhang X, Rielland M., Yalcin S., Ghaffari S.. Regulation and function of FoxO transcription factors in normal and cancer stem cells: what have we learned? Current Drug Targets. 2011 Aug 1;12(9):1267-83.


Ghaffari S. Cancer, Stem Cells and Cancer Stem Cells: Old Ideas, New Developments. F1000 Medicine Reports 2011 3:(23) (01 Dec 2011)


29- Rimmelé P., Zhang, X. and S. Ghaffari. Rôle des Facteurs de Transcription FoxOs Dans la Maintenance des Cellules Souches, Revue Médecine Sciences 2012, n 3, (28): 33-37.


2007-2010


Yalcin S, Marinkovic D., Mungamuri SK, Zhang X., Tong W., and S. Ghaffari. ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3(-/-) mice. EMBOJ, 29(24):4118-31, 2010. Epub 2010 Nov 26.


Yu D., dos Santos C.O., Zhao G., Jiang J., Amigo J.D., Khandros E., Dore L.C., Yao Y., D’Souza J., Zhang Z., Ghaffari S., Choi J., Friend S., Tong W., Orange J.S., Paw B.H., and M.J. Weiss. miR-451 protects against erythroid oxidant stress by repressing 14-3-3z. Genes & Development 24(15):1620-33, 2010.


Yalcin S, Zhang X., Marinkovic D., Luciano J.P., Sarkar A., Brugnara C., Vercherat C., Taneja R. and S. Ghaffari. Foxo3 is essential for the regulation of ataxia telangiectasia mutated and oxidative stress-mediated homeostasis of hematopoietic stem cells. Journal of Biological Chemistry, 283:25692-25705, 2008.


Marinkovic D., Zhang X., Yalcin S., Brugnara C., Huber T., and S. Ghaffari. Foxo3 is required for the regulation of oxidative stress in erythropoiesis.Journal of Clinical Investigation, 117 (8): 2133-2144, 2007 (Highlighted in Commentary: JCI, 107 (8): 2075-2077, 2007).


Sun H, Ghaffari S. and R. Taneja. bHLH-Orange transcription factors and cancer. Translational Oncogenomics, (2): 105-118, 2007.


S. Ghaffari. Oxidative stress in the regulation of normal and neoplastic hematopoiesis, (Forum Issue) Antioxidants & Redox Signaling 10:1923-1940, 2008.


Jagani Z., Song K., Kutok JL., Dewar MR., Melet A., Santos T., Grassian A., Ghaffari S., Wu C., Ren R., Rodin HY, Miller K, Khosravi-Far R. Proteasome inhibition causes regression of leukemia and abrogates BCR-ABL-induced evasion of apoptosis in part through regulation of forkhead tumor suppressors. Cancer Research, 69(16):6546-55, 2009.


Vercherat C., Chung TK, Yalcin S., Gulbagci N., Gopinadhan S., Ghaffari S., and R. Taneja. Stra13 regulates oxidative stress mediated skeletal muscle degeneration. Human Molecular Genetics, 18(22):4304-16, 2009.


Pervaiz. S., Taneja R., and S. Ghaffari. Oxidative Stress Regulation of Stem and Progenitor Cells (Forum Issue) Antioxidants & Redox Signaling 11(11):2777-89, 2009.


* Contributed equally