Cagan Lab - Publications


Publications since:


Levine B and Cagan R. (2016). Drosophila Lung Cancer Models Identify Trametinib Plus A Statin as a Candidate Therapeutic. Cell Reports, doi: 10.1016/j.celrep.2015.12.105.

Bangi E, Murgia C, Teague A, Sansom O., and Cagan R. (2016). Functional exploration of colorectal cancer genomes using Drosophila. Nature Communications doi: 10.1038/ncomms13615.


Na J, Sweetwyne M, Park A, Susztak, K, and Cagan, R. (2015). Diet Induced Podocyte Dysfunction in Drosophila and in Mammals. Cell Reports Jul 28;12(4):636-47.

Cagan R. (2015). Embracing risk. Dis Model Mech. 2015 Aug 1;8(8):767.

Hirabayashi S and Cagan R. (2015). Salt-Inducible Kinases Mediate Nutrient-Sensing To Link Dietary Sugar and Tumorigenesis in Drosophila. eLife, 17;4. doi: 10.7554/ eLife.08501.


Rudrapatna V, Bangi E, and Cagan R. (2014). A Rho-Cofilin-Jnk Positive Feedback Network Directs Src Driven Invasion. Oncogene doi: 10.1038/onc.2013.232.


Hirabayashi S, Baranski T, and. Cagan R. (2013).  Transformed Drosophila Cells Evade Diet-Mediated Insulin Resistance Through Wingless Signaling.  Cell 154(3):664-75.

Na J, Musselman LP, Pendse J, Baranski TJ, Bodmer R, Ocorr K, and Cagan R. (2013).  A Drosophila Model of High Sugar Diet-Induced cardiomyopathy.  PLOS Genetics Jan;9(1):e1003175.


Dar AC, Das T, Shokat KM, and Cagan R. (2012)  Chemical Genetic Discovery of Targets and Anti-targets for Polypharmacological Treatment of Cancer.  Nature 486(7401):80-4.

Das TK, Sangodkar J, Negre N, Narla G, and Cagan, R. (2012).  Sin3a Acts through a Multi-Gene Module to Regulate Invasion in Drosophila and Human Tumors.  Oncogene onc.2012.326

Rudrapatna VA, Cagan RL, Das TK. (2012). Drosophila cancer models. Dev Dyn. 2012 Jan;241(1):107-18.


Johnson R., Sedgwick A, D’Souza-Schorey C, and Cagan R (2011). Role for a Cindr-Arf6 axis in patterning emerging epithelia. Mol. Biol. Cell, 22(23):4513-26.

Musselman L., Fink J., Narzinski K., Ramachandran P., Sukumar S., Cagan R., and Baranski T. (2011). A high sugar diet produces obesity and insulin resistance in wild type Drosophila. Dis. Mod. & Mech. 4(6):842-9.

Cagan R. (2011). The Drosophila nephrocyte. Curr Opin Nephrol Hypertens. 20(4):409-15.


Tirtha Das and Ross Cagan (2010). Drosophila as a Novel Therapeutic Discovery Tool for Thyroid Cancer Thyroid 20(7):689-695.

Kasai Y, Cagan R. (2010). Drosophila as a tool for personalized medicine: a primer. Per Med. 7(6):621-632.

Cagan R. and Reh T. (2010). Aspects of eye development: advances over the past twenty years. Curr Top Dev Biol. 93:xi-xii.

Larson D., Johnson R., Swat M., Cordero J., Glazier J. and Cagan R. (2010). Computer Simulation of Cellular Patterning Within the Drosophila Pupal Eye. PLoS Computational 6:e1000841.

Bao S, Fischbach KF, Corbin V, Cagan RL. (2010). Preferential adhesion maintains separation of ommatidia in the Drosophila eye. Dev Biol. 15;344(2):948-56.

Cordero J., Macagno, J., Stefanatos, R., Strathdee, K., Cagan, R., and Vidal (2010). Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter. Dev Cell, 15;18(6):999-1011.

Das T. and Cagan R. (2010). Drosophila as a novel therapeutic discovery tool for thyroid cancer. Thyroid, 20(7):689-95.

Vidal, M., Salavaggione, L., Ylagan, L., Wilkins, M., Watson, M., Weilbaecher, K., Cagan, R. (2010). A Role for the Epithelial Microenvironment at Tumor Boundaries: Evidence from Drosophila and Human Squamous Cell Carcinomas. Am J Pathol. 176(6):3007-14.

Cordero J., Cagan R. (2010). Canonical wingless signaling regulates cone cell specification in the Drosophila retina. Dev Dyn. 239(3):875-84.


Cagan R. (2009). Principles of Drosophila eye differentiation. Curr Top Dev Biol. 2009;89:115-35.

Johnson R.I., and Cagan R. (2009). A quantitative method to analyze Drosophila pupal eye patterning. PLoS One. Sep 15;4(9):e7008.


Larson, D., Liberman, Z., and Cagan, R.  (2008). Cellular Behavior in the Developing Drosophila Pupal Retina. Mech. Dev. 125(3-4):223-234.

Johnson RI, Seppa MJ, Cagan R. (2008).The Drosophila CD2AP/CIN85 orthologue Cindr regulates junctions and cytoskeleton dynamics during tissue patterning. J Cell Biol.180(6):1191-204.

Seppa M.J., Johnson R.I., Bao S., and Cagan R. (2008). Polychaetoid controls patterning by modulating adhesion in the Drosophila pupal retina. Dev Biol. 1;318(1):1-16.


Cordero, J., Larson, D., Craig, C., Hays, R., and Cagan, R. (2007). Dynamic Decapentaplegic signaling regulates patterning and adhesion in the Drosophila pupal retina. Development 134:1861-71.

Vidal M, Warner S, Read R and Cagan R. Differing Src signaling levels have distinct outcomes in Drosophila. Cancer Research 67(21):10278-85.


Vidal, M. and Cagan, R. (2006). Drosophila models for cancer research. Curr. Op. Genet. Dev. 16(1): 10-16

Bao, S. and Cagan, R. (2006)Fast cloning inverted repeats for RNA interference. RNA 12(11):2020-4

Vidal, M., Larson, D. Read, R., and Cagan, R. (2006). Drosophila Csk regulates oncogenic growth through multiple mechanisms. Developmental Cell, 10(1):33-44.

Borghese L, Fletcher G, Mathieu J, Atzberger A, Eades WC, Cagan RL, and Rorth P. (2006). Systematic analysis of the transcriptional switch inducing migration of border cells. Developmental Cell. 10(4):497-508.


Read, R., Goodfellow, P., Mardis, E., Novack, N., and Cagan, R. (2005). A Drosophila model of Multiple Endocrine Neoplasia Type 2. Genetics 171, 1057-81.

Bao, S. and Cagan, R. (2005). Preferential Adhesion mediated by Hibris and Roughest Regulates Morphogenesis and Patterning in the Drosophila Eye. Developmental Cell 8(6), 925-35.

Vidal, M., Wells, S., Ryan, A., and Cagan, R. (2005). ZD6474 supresses oncogenic Ret isoforms in a Drosophila model for Type 2 Multiple Endocrine Neoplasia Syndromes and Papillary Thyroid Carcinoma. Cancer Research 65(9), 3538-41.


Read, R., Bach, E., and Cagan, R. (2004). Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways. Mol Cell Biol 24(15), 6676-89.

Rusconi, J. and Cagan, R. (2004). Klumpfuss regulates cell death in the Drosophila retina. Mech Dev. 121(6), 537-46.

Cordero, J., Jassim, O., Bao, S., and Cagan, R. (2004). A Role for Wingless in an Early Pupal Cell Death Event that Contributes to Patterning the Drosophila Eye. Mech. Dev. 121(12), 1523-30.

Craig, C., Fink, J., Yai, Y., Ip, T., and Cagan, R. (2004). A Drosophila p38 ortholog is required for environmental stress responses. EMBO R 5(11), 1058-63.


Spencer, S. and Cagan, R. (2003). Echinoid is essential for regulation of EGFR signaling and R8 formation during Drosophila eye development. Development 130(16), 3725-33.

Cagan, R. (2003). The signals that drive kidney development: a view from the fly eye.  Curr. Op. Neph. Hypert. 12, 11-18.

Cagan, R. (2003). Spermatogenesis: borrowing the apoptotic machinery. Curr Biol. 5;13(15), R600-2.

Jassim, O., Fink, J., and Cagan, R. (2003). P53 protects the Drosophila retina from a developmentally-regulated DNA damage response. EMBO J (20), 5622-32.


Hays, R., Craig, C., and Cagan, R. (2002). Programmed death in eye development. In Drosophila Eye Development, Springer-Verlag 37, 169-189.

Hays, R., Wickline, L., and Cagan, R. (2002). Degradation of a Drosophila IAP by the morgue ubiquitin conjugase. Nature Cell Biology 6, 425-31.


Mills, J., Roth, K., Cagan, R., and Gordon, J. (2001). DNA microarrays and beyond: completing the journey from tissue to cell. Nature Cell Biology 3, 175-178 (Commentary).


Nowotny, P., Gorski, S., Han, S., Philips, K., Nowotny, V., Jones, C., Clark, R., Cagan, R., and Goate, A. (2000). Alternative splicing and post-translational modification in the Drosophila melanogaster presinilin. Molecular and Cellular Neuroscience 15, 88-98.

Miller, D. T., Read, R. and Cagan, R. L. (2000). The Drosophila primo locus encodes two low molecular weight tyrosine phosphatases. Gene 243 ( 2000), 1–9.

Brachmann, C., Jassim, O., and Cagan, R. (2000). DBorg-1 is a Drosophila Bcl-2 family member that functions in the apoptotic response to DNA damage. Current Biology 10(9), 547-50.

Tanenbaum, S., Gorski, S., and Cagan, R. L. (2000). Genetic modifiers of the Drosophila irreC-rst locus I: potential new regulators of retinal development and programmed cell death. Genetics 156, 205-217.

Gorski, S., Brachmann, C., Tanenbaum, S., and Cagan, R. (2000). Delta and Notch promote correct localization of IrreC-rst. Cell Death and Differentiation 7, 1011-1013.

Powell, P., Wesley, C., Spencer, S., and Cagan, R. L. (2000). Scabrous mediates long-range signaling by Notch. Nature 409, 626-630.


Miller, D. T. and Cagan, R. L. (1998). Local induction of patterning and programmed cell death in the developing Drosophila retina. Development 125(12):2327-2335.

Spencer, S., Powell, P., and Cagan, R. L. (1998). Regulation of Epidermal Growth Factor Receptor signaling establishes pattern across the developing Drosophila retina. Development 125, 4777-4790.


Kopan, R. and Cagan, R. L. (1997). Notch on the cutting edge. Trends in Genetics 13(12):465-467.


Dokuju, M., Zipursky, S. L., and Cagan, R. L. (1996). Atonal, Rough, and the resolution of proneural clusters in the developing Drosophila retina. Development 122: 4139-4147.


Reh T. and Cagan, R. L. (1994). Intrinsic and extrinsic signals in the developing vertebrate and fly eyes: viewing vertebrate and invertebrate eyes in the same light. Perspectives on Developmental Neurobiology 2: 183-190.


Cagan, R. L. (1993). Cell fate specification in the developing Drosophila retina. Development (supplement). 19-28.

Krämer H. and Cagan, R. L. (1993). Determination of photoreceptor cell fate in the Drosophila retina. Current Biology. 14-20.


Cagan, R. L., Krämer, Helmut, Hart Anne C., and Zipursky, S. L. (1992). The bride of seven-less and sevenless interaction: internalization of a transmembrane ligand. Cell 69: 393-399.

Cagan, R. L. and Zipursky, S. L. (1992). Cell choice and patterning in the Drosophila retina. In Determinants of Neuronal Identity (ed. E. Macagno and M. Shankland). Academic Press, San Diego. 189-224.

Rogge, R., Cagan, R. L., Majumdar, A., Delaney, T., and Banerjee, U. (1992). Neuronal development in the Drosophila retina: the sextra gene defines an inhibitory component in the developmental pathway of the R7 photoreceptor cell. Proc. Nat. Acad. Sci. USA 89:5271-5275.

Cagan, R. L., Thomas, B., and Zipursky, S. L. (1992). The role of induction in cell choice and cell cycle in the developing Drosophila retina. In Molecular Basis of Morphogenesis. 51st Annual Symposium of the Society for Developmental Biology, M. Bernstein (ed.) Wiley-Liss. 109-133.

Zipursky, S. L., Kramer, H., Cagan, R. L., Hart A., Van Vactor Jr., D. (1992). Induction of the R7 neuron in the Drosophila compound eye: the bride of sevenless and sevenless interaction. Cold Spring Harbor Symposia on Quantitative Biology 57:381-9.


Krämer, H., Cagan, R. L., and Zipursky, S. L. (1991). Interaction of bride of sevenless membrane-bound ligand and the sevenless tyrosine kinase receptor. Nature 352: 207-212.

Van Vactor Jr., D. L., Cagan, R. L., Krämer, H., and Zipursky, S. L. (1991). Induction in the developing compound eye of Drosophila: multiple mechanisms restrict R7 induction to a single retinal precursor cell. Cell 67: 1145-1155.


Cagan, R. L. and Ready, D. F. (1989). Notch is required for successive cell decisions in the developing Drosophila retina. Genes and Development 3: 1099-1112.

Cagan, R. L. and Ready, D. F. (1989). The emergence of order in the Drosophila pupal retina. Developmental Biology 136: 346-362.