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http://icahn.mssm.edu/departments-and-institutes/developmental-and-regenerative-biology
 

Blenkinsop Lab - Research

Retina disease and regeneration.

    Timothy Blenkinsop's laboratory works to understand the basic biology of the adult human eye in an effort to reveal mechanisms for regeneration. We are currently focused on RPE and RPE related diseases. Our approach is to develop in vitro models of the adult human RPE layer from human donors with RPE related disease in order to more carefully study disease pathology and identify compounds that can improve disease progression. We also explore the epigenetic state of RPE in normal and pathological conditions in order to understand how the cell state is regulating gene expression. Finally, we are attempting to develop a transplantation method whereby healthy human RPE from donors can be transplanted into patients where RPE are damaged or lost to preserve or improve vision.

lab info



Timothy Blenkinsop
ASSISTANT PROFESSOR
timothy.blenkinsop@mssm.edu

212-659-8278 (office / lab)
212-803-6740 (fax)

lab members:
...

see photos and more here.
mailto:timothy.blenkinsop@mssm.edu?subject=blenkinsoplab.htmlblenkinsoplab.htmlshapeimage_15_link_0shapeimage_15_link_1shapeimage_15_link_2
key publications

2014
Stanzel BV, Liu Z, Somboonthanakij S, Wongsawad W, Brinken R, Eter N, Corneo B, Holz FG, Temple S, Stern JH, Blenkinsop TA.,
Human RPE Stem Cells Grown into Polarized RPE Monolayers on a Polyester Matrix Are Maintained after Grafting into Rabbit Subretinal Space.  
Stem cell reports, Jan; 2(1).

2012
Salero E.,* Blenkinsop T.A.,* Corneo B., Harris A., Rabin D., Stern J., Temple S.,
Adult human RPE can be activated into a multipotent stem cell that produces mesenchymal derivatives.
Cell Stem Cell, Jan 6; 10 (1): 88-95.

see more publications here.blenkinsoppub.htmlshapeimage_17_link_0
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